After her father's death, her mother moved to Cleveland, Ohio, leaving her to be reared by foster parents, Emma (née Reiss; 1866 – 1951) Her unsettled family life resulted in few pleasurable memories.Wyman later said, "I was raised with such strict discipline that it was years before I could reason myself out of the bitterness I brought from my childhood." In 1928, aged 11, she moved to southern California with her foster mother.I think I'll do it again." The Oscar win gave her the ability to choose higher-profile roles, although she still showed a liking for musical comedy.She worked with such directors as Alfred Hitchcock on Stage Fright (1950), Frank Capra on Here Comes the Groom (1951), and Michael Curtiz on The Story of Will Rogers (1952).Wyman followed common practice at the time when she added three years to her age.A popular contract player, she frequently played the leading lady, her roles including starring alongside William Hopper in Public Wedding (1937), Ronald Reagan and Eddie Albert in Brother Rat (1938) and its sequel Brother Rat and a Baby (1940), Dennis Morgan in Bad Men of Missouri (1941), Marlene Dietrich in Stage Fright (1950), and Sterling Hayden in So Big (1953).She was the first person in the sound era to win an acting Oscar without speaking a line of dialogue.
She signed a contract with Warner Brothers in 1936.
She starred in The Glass Menagerie (1950), Just for You (1952), Let's Do It Again (1953), The Blue Veil (1951) (another Oscar nomination), the remake of Edna Ferber's So Big (1953), Magnificent Obsession (1954) (Oscar nomination), Lucy Gallant (1955), All That Heaven Allows (1955), and Miracle in the Rain (1956).
She replaced the ailing Gene Tierney in Holiday for Lovers (1959), and next appeared in Pollyanna (1960), Bon Voyage!
She was hostess of The Bell Telephone Hour and Bob Hope Presents The Chrysler Theatre.
She had telling roles in both The Sixth Sense and Insight, among other programs.